Colorectal Cancer Part 5: review of the medical literature: Not all patients benefit from chemotherapy
After surgery, microscopic cancer cells are still left in the body. As an "insurance policy" Patients are told by their oncologists to undergo chemotherapy or radiotherapy (or both). The idea is to kill cancer cells, which remain on track. But how effective is it? How valid is the hypothesis that chemotherapy alone is?
I invite you to the following research work to read them some serious thought. Form your own opinion about what you wantwe want the event suffering from the first phase (Phase 2), colon cancer, too.
Scholefield JH, in an article: "The challenges of colon cancer." (Book Review. New England J of Medicine. September 2000. Vol: 343:893. Wrote):
"Cancer of the colon presents some of the most annoying problems for basic scientists, clinical researchers and professionals. Surgery remains the center of attention."
Question: In all these years, why is the treatment ofcolorectal cancer 'biggest challenge? " Is the treatment of colorectal cancer protocol does not work yet?
Moertel, CG (in chemotherapy for colon cancer. New England J. of Medicine. April 1994. Vol 330: 1136-1142) wrote:
Tumor shrinkage "Radiation therapy plays only a palliative role. In the past, chemotherapy is rare and usually transient tours. The use is not justified in view of the inconvenience and cost of treatment. However,today there has been some progress. "
Question: The author is a renowned oncologist at the famous Mayo Clinic. It 'very surprising to note that "in the past, chemotherapy has only resulted in temporary tumor shrinkage." Although shrinkage is rarely achieved. But then we were to believe that chemotherapy was necessary. It was a mistake, then? Chemotherapy was justified in the past? And the present? There will be a further error in the street? The author iswhich means that now, perhaps, all right – we see some progress? Chemotherapy, which still is not a pleasant experience, while in some patients, said he suffered a lot. Furthermore, it is still cost a lot of money. Is the current situation to change?
Piedbois Buyse M & P. (where: Duke's B patients receive adjuvant therapy? A statistical point of view. Semin. Oncol. In 2001. (Suppl. 1): wrote 20-24):
"The benefit of adjuvant therapy, such as 5-FU + leucovorin, is a matter of debate forPatients with colon cancer Duke's B. Five different studies have shown no significant benefit of adjuvant 5-FU + leucovorin compared with surgery alone. "
Benson, AB, et al. (In: American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J. of Clinical Oncology, August 2004. Vol: 22: 3408-3419) wrote:
"Elements of direct evidence from randomized controlled trials does not support the routine use of adjuvant chemotherapy forPatients with stage II colon cancer. Therefore, the routine use of adjuvant chemotherapy to medically fit patients with stage II colon cancer is not recommended. "
Figueredo, A. et al. (in: adjuvant therapy for stage II colon cancer: A systematic review of Cancer Care Ontario Program in Evidence-Based Gastrointestinal Cancer Disease Site Group. J. of Clinical Oncology, August 2004. Vol: 16: 3395-3407) wrote:
"The benefits of adjuvant therapyChemotherapy are small and not necessarily associated with improved overall survival. Patients should be informed of these results. "
With that cancer research would take a pause and think seriously enough prior to "follow" what they want to oncologists?
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